8-30-18  68F with falls and lethargy found to have ecchymoses. Labs: hemolytic anemia, thrombocytopenia Diagnosis: likely DIC. CLINICAL QUESTION Q: How reliable is the presence of schistocytes to diagnose TMA? A: Automated count is significantly lower than microscopic count; TMA had significantly higher schistocyte count than nonTMA (consider higher threshold to diagnose TMA “The Clinical […]

Another great review article from NEJM has arrived. Israel, E., & Reddel, H. K. (2017). Severe and Difficult-to-Treat Asthma in Adults. New England Journal of Medicine, 377(10), 965–976. http://doi.org/10.1056/NEJMra1608969 Titled “Severe and Difficult-to-Treat Asthma in Adults”, this article summarizes the most recent pathophysiological concept of asthma and airway remodeling.

Anyone interested in learning about how to effectively write scientific papers? Stanford online (now called “Stanford lagunita”) is enrolling a new 8 week course of online e-learning module. Please access this link if you’re interested. https://www.coursera.org/learn/sciwrite Unit 1 introduces the course and reviews key principles of effective writing. In particular, you will practice cutting clutter […]

2014 JAMA “Serum ammonia level for the evaluation of hepatic encephalopathy.” PMID: 25117134 This short synopsis summarizes the current utility of serum ammonia level. In acute liver failure, ammonia levels have prognostic significance. In one study, an arterial ammonia level of 124 μmol/L (211 μg/dL) or higher predicted mortality with 78.6% sensitivity, 76.3% specificity, and […]